The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

Jul 3, 2017

11.2K

Whole Genome Sequencing
Whole Exome Sequencing
RNA Sequencing
SNP Array

Heatmap summarizing target genes within pediatric and young adult T-lineage acute lymphoblastic leukemia from Liu et al. 2017 (representative of Fig. 5). Samples are grouped by deregulated gene status (TAL1, TLX3, TLX1, HOXA, LMO2/LYL1, NKX2-1, LMO1/2, and TAL2). The ETP, TRG and 6q del status is also described for each sample. Mutations in genes (rows) are defined as per legend. Mousing over each instance of a mutation provides further information (sample, mutation type, amino acid change, and gene name). Clicking on each gene symbol opens a ProteinPaint view of mutations found within the gene within samples in this cohort. Numbers in parentheses next to each gene symbol indicate the number of samples altered.

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