The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.
Heatmap summarizing target genes within pediatric and young adult T-lineage acute lymphoblastic leukemia from Liu et al. 2017 (representative of Fig. 5). Samples are grouped by deregulated gene status (TAL1, TLX3, TLX1, HOXA, LMO2/LYL1, NKX2-1, LMO1/2, and TAL2). The ETP, TRG and 6q del status is also described for each sample. Mutations in genes (rows) are defined as per legend. Mousing over each instance of a mutation provides further information (sample, mutation type, amino acid change, and gene name). Clicking on each gene symbol opens a ProteinPaint view of mutations found within the gene within samples in this cohort. Numbers in parentheses next to each gene symbol indicate the number of samples altered.