Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

Oct 24, 2016

10.4K

Whole Genome Sequencing
Whole Exome Sequencing
RNA Sequencing

Displaying a heatmap showing genomic data for DUX4/ERG ALL cases (columns); genes (rows) are grouped by functional pathway. The color for each type of genetic alteration is defined as per legend. The genomic profiling performed and presence/absence of ERGalt, ALE (Antisense long non-coding RNA associated with ERG) and DUX4 rearrangement are shown at the top: yellow, assay performed or alteration present; white, assay not performed or alteration absent; dark grey, data not available. WGS, whole-genome sequencing; RNA, RNA-seq analysis; WES, whole-exome sequencing. Visualization representative of Zhang et al. 2016, Fig. 3. Mousing over each instance of a mutation provides further information (sample, mutation type, amino acid change, and gene name). Clicking on each gene symbol opens a ProteinPaint view of mutations found within the gene for this cohort. Numbers next to each gene symbol in parentheses indicate the number of samples altered.

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