3D Chromatin HiC data of Neuroblastoma Cell Line SH-SY5Y

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

Sep 26, 2022

< 1k


This HiC data combines chromatin localization frequency and RefSeq gene models for a pediatric neuroblastoma cell line SH-SY5Y. The hg19 genome location is navigable. The intensity of red is proportional to the frequency of association between sites. This demonstration graphic was rendered using GenomePaint. Significantly, this visualization demonstrates the capacity to should inter-chromosomal interactions as well as intra-chromosonal ones. Structural variants and other mutations within the selected defined chromosome location from the SJCloud Pediatric2 cohort are rendered as a new track by selecting the Pediatric2 button. Specifically, in SH-SY5Y cells, a super-enhancer within the EXOC4 gene locus on chromosome 7 is translocated to less than a megabase downstream from the c-MYC transcriptional start site. The super-enhancer within the EXOC4 gene joins c-MYC in a newly formed TAD on the derivative chromosome. To view the global overview of this cell line data go here.

Read more
Loading Visualization
Visualization Code