Visualizations

This study integrates single-cell transcriptomic profiles of 89 B-ALL samples with normal B-cell development to map their developmental origins. It reveals that certain subtypes (BCR::ABL1, KMT2A-R, DUX4-R, ZNF384-R) resemble early multipotent progenitors, ret...

This portal consolidates clinical, molecular and survival data from 898 patients across three major trials (ACNS0331, ACNS0332, SJMB03). The portal integrates clinical data with genomic mutations and DNA methylomes, enabling in-depth analysis of tumor subgroup...

The data portal features comprehensive information from 64 patients diagnosed with recurrent or treatment-refractory pediatric atypical teratoid rhabdoid tumor (AT/RT). This resource provides valuable insights into the association between molecular groups, his...

Medulloblastoma patients were stratified into average-risk and high-risk treatment groups based on metastatic status and extent of resection as part of SJMB03. Medulloblastomas were molecularly classified into subgroups (Wingless [WNT], Sonic Hedgehog [SHH], g...

Cancer genomics has revealed many genes and core molecular processes that contribute to human malignancies, but the genetic and molecular bases of many rare cancers remains unclear. Genetic predisposition accounts for 5 to 10% of cancer diagnoses in children a...

Children and infants who experienced medulloblastoma relapse donated tumor samples which were analyzed by DNA methylation array and next-generation sequencing. The primary-relapse pairs. The results below are arrayed by subgroup with age, sex and metadata pro...

Fifty-six tumors previously diagnosed as High-Grade Glioma in patients younger than 5- years were re-characterized using histology, next-generation sequencing, and methylation. Through molecular interrogation of these tumors, we identified that they are biolo...

This visualization compares mutations in pediatric cancer samples inferred to have age-related (iAR) variants to mutations from samples inferred to have therapy-related (iTR) variants. The samples cover a wide range of diagnoses. Note that several have auto...

This HiC data combines chromatin localization frequency and RefSeq gene models for a pediatric neuroblastoma cell line SH-SY5Y. The hg19 genome location is navigable. The intensity of red is proportional to the frequency of association between sites. This demo...