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The mutational landscape of core-binding factor acute myeloid leukemias

St. Jude Children's Research Hospital

48 4

Oct 31, 2016

PMID 27798625

9.4K

Whole Genome Sequencing

Whole Exome Sequencing

Mutational data for 165 CBF-AML cases sequenced either by whole-genome (n = 17) or whole-exome (n = 148) sequencing are displayed. Two fusion subgroups are compared (RUNX1-RUNX1T1 and CBFB-MYH11). Signaling, epigenetic and cohesin genes are separated into functional groups. Cytogenetic abnormalities (Del(9q), -X/-Y, +8, -5/-7, and Complex), patient age group (adult or pediatric), and fusion status are indicated. Visualization representative of Faber, et al. 2016, Figure 1a. Mousing over each instance of a mutation provides further information (sample, mutation type, amino acid change, and gene name). Clicking on each gene symbol opens a ProteinPaint view of mutations found within the gene for this cohort. Numbers in parentheses next to each gene symbol indicate the number of samples altered.

Loading Visualization

runproteinpaint({
  host: "https://proteinpaint.stjude.org",
  holder: visualizationContainer[0],
  nobox: 1,
  noheader: true,
  genome: "hg19",
  studyview: {
    hide_navigation: 1,
    name: "CBF_AML",
    mutationset: [{
      snvindel: "dfinkels/CBF_AML/ID1_indel_v2.txt",
      svjson: "dfinkels/CBF_AML/ID1_fusion.txt"
    }],
    show_heatmap: 1,
    heatmapJSON: {
  "metadataborder": "black",
  "samplegroup": [
    {
      "name": "RUNX1-RUNX1T1",
      "lst": [
        {
          "name": "SJCBF177_D"
        },
        {
          "name": "SJCBF034_D"
        },
        {
          "name": "SJCBF080_D"
        },
        {
          "name": "SJCBF173_D"
        },
        {
          "name": "SJCBF044_D"
        },
        {
          "name": "SJCBF086_D"
        },
        {
          "name": "SJCBF179_D"
        },
        {
          "name": "SJCBF087_D"
        },
        {
          "name": "SJCBF166_D"
        },
        {
          "name": "SJCBF098_D"
        },
        {
          "name": "SJCBF112_D"
        },
        {
          "name": "SJCBF108_D"
        },
        {
          "name": "SJCBF117_D"
        },
        {
          "name": "SJCBF084_D"
        },
        {
          "name": "SJCBF031_D"
        },
        {
          "name": "SJCBF125_D"
        },
        {
          "name": "SJCBF030_D"
        },
        {
          "name": "SJCBF172_D"
        },
        {
          "name": "SJCBF043_D"
        },
        {
          "name": "SJCBF147_D"
        },
        {
          "name": "SJCBF111_D"
        },
        {
          "name": "SJCBF164_D"
        },
        {
          "name": "SJCBF176_D"
        },
        {
          "name": "SJCBF181_D"
        },
        {
          "name": "SJCBF078_D"
        },
        {
          "name": "SJCBF169_D"
        },
        {
          "name": "SJCBF003_D"
        },
        {
          "name": "SJCBF180_D"
        },
        {
          "name": "SJCBF167_D"
        },
        {
          "name": "SJCBF077_D"
        },
        {
          "name": "SJCBF100_D"
        },
        {
          "name": "SJCBF001_D"
        },
        {
          "name": "SJCBF145_D"
        },
        {
          "name": "SJCBF141_D"
        },
        {
          "name": "SJCBF029_D"
        },
        {
          "name": "SJCBF088_D"
        },
        {
          "name": "SJCBF178_D"
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        {
          "name": "SJCBF004_D"
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        {
          "name": "SJCBF195_D"
        },
        {
          "name": "SJCBF163_D"
        },
        {
          "name": "SJCBF083_D"
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        {
          "name": "SJCBF006_D"
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        {
          "name": "SJCBF165_D"
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        {
          "name": "SJCBF079_D"
        },
        {
          "name": "SJCBF193_D"
        },
        {
          "name": "SJCBF184_D"
        },
        {
          "name": "SJCBF192_D"
        },
        {
          "name": "SJCBF048_D"
        },
        {
          "name": "SJCBF139_D"
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          "name": "SJCBF101_D"
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          "name": "SJCBF009_D"
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          "name": "SJCBF191_D"
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          "name": "SJCBF094_D"
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          "name": "SJCBF175_D"
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          "name": "SJCBF124_D"
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          "name": "SJCBF008_D"
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          "name": "SJCBF182_D"
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          "name": "SJCBF040_D"
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          "name": "SJCBF049_D"
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          "name": "SJCBF091_D"
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          "name": "SJCBF142_D"
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        {
          "name": "SJCBF146_D"
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          "name": "SJCBF081_D"
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        {
          "name": "SJCBF011_D"
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          "name": "SJCBF028_D"
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          "name": "SJCBF120_D"
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          "name": "SJCBF138_D"
        },
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          "name": "SJCBF102_D"
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          "name": "SJCBF150_D"
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          "name": "SJCBF039_D"
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          "name": "SJCBF097_D"
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          "name": "SJCBF085_D"
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          "name": "SJCBF143_D"
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          "name": "SJCBF149_D"
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          "name": "SJCBF168_D"
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          "name": "SJCBF171_D"
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          "name": "SJCBF183_D"
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        },
        {
          "name": "SJCBF069_D"
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        {
          "name": "SJCBF105_D"
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        {
          "name": "SJCBF053_D"
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          "name": "SJCBF038_D"
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        {
          "name": "SJCBF014_D"
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        {
          "name": "SJCBF065_D"
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        {
          "name": "SJCBF187_D"
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        {
          "name": "SJCBF022_D"
        },
        {
          "name": "SJCBF032_D"
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        {
          "name": "SJCBF061_D"
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        {
          "name": "SJCBF026_D"
        },
        {
          "name": "SJCBF153_D"
        },
        {
          "name": "SJCBF012_D"
        },
        {
          "name": "SJCBF016_D"
        },
        {
          "name": "SJCBF033_D"
        },
        {
          "name": "SJCBF035_D"
        },
        {
          "name": "SJCBF037_D"
        },
        {
          "name": "SJCBF050_D"
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          "name": "SJCBF052_D"
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        {
          "name": "SJCBF058_D"
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        {
          "name": "SJCBF067_D"
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        {
          "name": "SJCBF068_D"
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        {
          "name": "SJCBF071_D"
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        {
          "name": "SJCBF090_D"
        },
        {
          "name": "SJCBF096_D"
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        {
          "name": "SJCBF114_D"
        },
        {
          "name": "SJCBF121_D"
        },
        {
          "name": "SJCBF123_D"
        },
        {
          "name": "SJCBF148_D"
        },
        {
          "name": "SJCBF151_D"
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          "name": "SJCBF158_D"
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          "name": "SJCBF160_D"
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          "name": "SJCBF161_D"
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          "name": "SJCBF185_D"
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          "name": "SJCBF017_D"
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          "name": "SJCBF122_D"
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          "name": "SJCBF140_D"
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          "name": "SJCBF109_D"
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          "name": "SJCBF024_D"
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        {
          "name": "SJCBF055_D"
        },
        {
          "name": "SJCBF064_D"
        },
        {
          "name": "SJCBF074_D"
        },
        {
          "name": "SJCBF075_D"
        },
        {
          "name": "SJCBF113_D"
        },
        {
          "name": "SJCBF118_D"
        },
        {
          "name": "SJCBF189_D"
        },
        {
          "name": "SJCBF063_D"
        },
        {
          "name": "SJCBF059_D"
        },
        {
          "name": "SJCBF056_D"
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        {
          "name": "SJCBF025_D"
        },
        {
          "name": "SJCBF116_D"
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        {
          "name": "SJCBF190_D"
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        {
          "name": "SJCBF013_D"
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        {
          "name": "SJCBF106_D"
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        {
          "name": "SJCBF062_D"
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        {
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        {
          "name": "SJCBF093_D"
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        {
          "name": "SJCBF159_D"
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        {
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          "name": "SJCBF060_D"
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          "name": "SJCBF073_D"
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        {
          "name": "SJCBF076_D"
        },
        {
          "name": "SJCBF095_D"
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        {
          "name": "SJCBF104_D"
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        {
          "name": "SJCBF107_D"
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        {
          "name": "SJCBF137_D"
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        {
          "name": "SJCBF144_D"
        },
        {
          "name": "SJCBF155_D"
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          "name": "SJCBF188_D"
        }
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    },
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  },
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      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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    },
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      "+8": "no",
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      "Fusion only": "no",
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      "Fusion only": "no",
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "yes",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF087_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "yes",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
    "SJCBF122_D": {
      "Fusion subgroup": "i16",
      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "yes",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "yes",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "yes",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "yes",
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    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "yes",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "yes",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "yes",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "yes",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
    "SJCBF177_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "yes",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF178_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF179_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF180_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
    "SJCBF181_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
    "SJCBF182_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF183_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "yes",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF184_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
    "SJCBF185_D": {
      "Fusion subgroup": "i16",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF187_D": {
      "Fusion subgroup": "i16",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
    "SJCBF188_D": {
      "Fusion subgroup": "i16",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
    "SJCBF189_D": {
      "Fusion subgroup": "i16",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF190_D": {
      "Fusion subgroup": "i16",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF191_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF192_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF193_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF195_D": {
      "Fusion subgroup": "ae",
      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    }
  },
  "colw": 9,
  "rowh": 20,
  "rowspace": 2,
  "colspace": 0,
  "rowtick": 8,
  "coltick": 5,
  "rowlabtickspace": 4,
  "collabtickspace": 4,
  "collabelh": 60.171875,
  "rowlabelw": 150,
  "rowheadleft": true,
  "colheadtop": false,
  "samplecount4gene": true,
  "samplecount4legend": false,
  "showgrid": true,
  "gridstroke": "#fff",
  "showEmptyCells": false,
  "cellbg": "#eeeeee",
  "fontsizeratio": 0.9,
  "minrowlabelh": 0,
  "rowlabelfontsizemax": 16,
  "collabelfontsizemax": 12,
  "crudefill": false,
  "duration": 1000,
  "delay": 350,
  "colgspace": 4,
  "rowgspace": 4,
  "rowglabspace": 5,
  "colglabspace": 5,
  "colgrplabelh": 24,
  "rowgrplabelw": 24,
  "rowglabfontsize": 15,
  "rowglabfontsizemax": 25,
  "colglabfontsize": 15,
  "colglabfontsizemax": 25,
  "rowglabeladjust": {
    "margin": 5,
    "stackSign": -1,
    "tick": {
      "direction": 1,
      "centeron": "y",
      "extendon": "x"
    },
    "steps": [
      {
        "type": "wrap",
        "delim": " ",
        "lineh": 16
      },
      {
        "type": "resize",
        "fontsize": 12,
        "lineh": 12,
        "consistent": true
      },
      {
        "type": "rotate",
        "fontsize": 12,
        "lineh": 12
      }
    ]
  },
  "colglabeladjust": {
    "margin": 5,
    "tick": {
      "direction": -1,
      "centeron": "x",
      "extendon": "y"
    },
    "steps": [
      {
        "type": "wrap",
        "delim": " ",
        "lineh": 12
      },
      {
        "type": "resize",
        "fontsize": 12,
        "lineh": 12,
        "consistent": true
      },
      {
        "type": "rotate",
        "fontsize": 12,
        "lineh": 12
      }
    ],
    "stackSign": -1
  },
  "borderwidth": 1,
  "highlightColor": "#ff0",
  "legendontop": true,
  "legendh": 205,
  "legendlineh": 25,
  "legendpadx": 5,
  "legendpadleft": 150,
  "legendpadright": 20,
  "legendpadbtm": 30,
  "legendfontsize": 12,
  "legendiconh": 10,
  "legendiconw": 10,
  "legendhangleft": 1,
  "legendlinesep": false,
  "legendmutationorder": [
    "M",
    "E",
    "F",
    "N",
    "S",
    "D",
    "I",
    "P",
    "L",
    "Intron",
    "ITD",
    "DEL",
    "NLOSS",
    "CLOSS",
    "Utr3",
    "Utr5",
    "X",
    "noncoding",
    "Fuserna",
    "SV",
    "CNV_amp",
    "CNV_loss",
    "snv",
    "mnv"
  ],
  "rowfontsize": 16,
  "colfontsize": 8.1,
  "gridAnimate": false
  }
 }	
})

Visualization Code

runproteinpaint({
  host: "https://proteinpaint.stjude.org",
  holder: visualizationContainer[0],
  nobox: 1,
  noheader: true,
  genome: "hg19",
  studyview: {
    hide_navigation: 1,
    name: "CBF_AML",
    mutationset: [{
      snvindel: "dfinkels/CBF_AML/ID1_indel_v2.txt",
      svjson: "dfinkels/CBF_AML/ID1_fusion.txt"
    }],
    show_heatmap: 1,
    heatmapJSON: {
  "metadataborder": "black",
  "samplegroup": [
    {
      "name": "RUNX1-RUNX1T1",
      "lst": [
        {
          "name": "SJCBF177_D"
        },
        {
          "name": "SJCBF034_D"
        },
        {
          "name": "SJCBF080_D"
        },
        {
          "name": "SJCBF173_D"
        },
        {
          "name": "SJCBF044_D"
        },
        {
          "name": "SJCBF086_D"
        },
        {
          "name": "SJCBF179_D"
        },
        {
          "name": "SJCBF087_D"
        },
        {
          "name": "SJCBF166_D"
        },
        {
          "name": "SJCBF098_D"
        },
        {
          "name": "SJCBF112_D"
        },
        {
          "name": "SJCBF108_D"
        },
        {
          "name": "SJCBF117_D"
        },
        {
          "name": "SJCBF084_D"
        },
        {
          "name": "SJCBF031_D"
        },
        {
          "name": "SJCBF125_D"
        },
        {
          "name": "SJCBF030_D"
        },
        {
          "name": "SJCBF172_D"
        },
        {
          "name": "SJCBF043_D"
        },
        {
          "name": "SJCBF147_D"
        },
        {
          "name": "SJCBF111_D"
        },
        {
          "name": "SJCBF164_D"
        },
        {
          "name": "SJCBF176_D"
        },
        {
          "name": "SJCBF181_D"
        },
        {
          "name": "SJCBF078_D"
        },
        {
          "name": "SJCBF169_D"
        },
        {
          "name": "SJCBF003_D"
        },
        {
          "name": "SJCBF180_D"
        },
        {
          "name": "SJCBF167_D"
        },
        {
          "name": "SJCBF077_D"
        },
        {
          "name": "SJCBF100_D"
        },
        {
          "name": "SJCBF001_D"
        },
        {
          "name": "SJCBF145_D"
        },
        {
          "name": "SJCBF141_D"
        },
        {
          "name": "SJCBF029_D"
        },
        {
          "name": "SJCBF088_D"
        },
        {
          "name": "SJCBF178_D"
        },
        {
          "name": "SJCBF004_D"
        },
        {
          "name": "SJCBF195_D"
        },
        {
          "name": "SJCBF163_D"
        },
        {
          "name": "SJCBF083_D"
        },
        {
          "name": "SJCBF006_D"
        },
        {
          "name": "SJCBF165_D"
        },
        {
          "name": "SJCBF079_D"
        },
        {
          "name": "SJCBF193_D"
        },
        {
          "name": "SJCBF184_D"
        },
        {
          "name": "SJCBF192_D"
        },
        {
          "name": "SJCBF048_D"
        },
        {
          "name": "SJCBF139_D"
        },
        {
          "name": "SJCBF101_D"
        },
        {
          "name": "SJCBF009_D"
        },
        {
          "name": "SJCBF082_D"
        },
        {
          "name": "SJCBF170_D"
        },
        {
          "name": "SJCBF042_D"
        },
        {
          "name": "SJCBF191_D"
        },
        {
          "name": "SJCBF094_D"
        },
        {
          "name": "SJCBF175_D"
        },
        {
          "name": "SJCBF124_D"
        },
        {
          "name": "SJCBF008_D"
        },
        {
          "name": "SJCBF182_D"
        },
        {
          "name": "SJCBF040_D"
        },
        {
          "name": "SJCBF049_D"
        },
        {
          "name": "SJCBF091_D"
        },
        {
          "name": "SJCBF142_D"
        },
        {
          "name": "SJCBF146_D"
        },
        {
          "name": "SJCBF081_D"
        },
        {
          "name": "SJCBF011_D"
        },
        {
          "name": "SJCBF028_D"
        },
        {
          "name": "SJCBF174_D"
        },
        {
          "name": "SJCBF120_D"
        },
        {
          "name": "SJCBF138_D"
        },
        {
          "name": "SJCBF102_D"
        },
        {
          "name": "SJCBF150_D"
        },
        {
          "name": "SJCBF039_D"
        },
        {
          "name": "SJCBF097_D"
        },
        {
          "name": "SJCBF103_D"
        },
        {
          "name": "SJCBF051_D"
        },
        {
          "name": "SJCBF085_D"
        },
        {
          "name": "SJCBF099_D"
        },
        {
          "name": "SJCBF110_D"
        },
        {
          "name": "SJCBF143_D"
        },
        {
          "name": "SJCBF149_D"
        },
        {
          "name": "SJCBF168_D"
        },
        {
          "name": "SJCBF171_D"
        },
        {
          "name": "SJCBF183_D"
        }
      ]
    },
    {
      "name": "CBFB-MYH11",
      "lst": [
        {
          "name": "SJCBF152_D"
        },
        {
          "name": "SJCBF069_D"
        },
        {
          "name": "SJCBF105_D"
        },
        {
          "name": "SJCBF053_D"
        },
        {
          "name": "SJCBF070_D"
        },
        {
          "name": "SJCBF038_D"
        },
        {
          "name": "SJCBF014_D"
        },
        {
          "name": "SJCBF065_D"
        },
        {
          "name": "SJCBF187_D"
        },
        {
          "name": "SJCBF022_D"
        },
        {
          "name": "SJCBF032_D"
        },
        {
          "name": "SJCBF061_D"
        },
        {
          "name": "SJCBF026_D"
        },
        {
          "name": "SJCBF153_D"
        },
        {
          "name": "SJCBF012_D"
        },
        {
          "name": "SJCBF016_D"
        },
        {
          "name": "SJCBF033_D"
        },
        {
          "name": "SJCBF035_D"
        },
        {
          "name": "SJCBF037_D"
        },
        {
          "name": "SJCBF050_D"
        },
        {
          "name": "SJCBF052_D"
        },
        {
          "name": "SJCBF058_D"
        },
        {
          "name": "SJCBF067_D"
        },
        {
          "name": "SJCBF068_D"
        },
        {
          "name": "SJCBF071_D"
        },
        {
          "name": "SJCBF090_D"
        },
        {
          "name": "SJCBF096_D"
        },
        {
          "name": "SJCBF114_D"
        },
        {
          "name": "SJCBF121_D"
        },
        {
          "name": "SJCBF123_D"
        },
        {
          "name": "SJCBF148_D"
        },
        {
          "name": "SJCBF151_D"
        },
        {
          "name": "SJCBF158_D"
        },
        {
          "name": "SJCBF160_D"
        },
        {
          "name": "SJCBF161_D"
        },
        {
          "name": "SJCBF185_D"
        },
        {
          "name": "SJCBF020_D"
        },
        {
          "name": "SJCBF027_D"
        },
        {
          "name": "SJCBF041_D"
        },
        {
          "name": "SJCBF017_D"
        },
        {
          "name": "SJCBF122_D"
        },
        {
          "name": "SJCBF140_D"
        },
        {
          "name": "SJCBF109_D"
        },
        {
          "name": "SJCBF024_D"
        },
        {
          "name": "SJCBF055_D"
        },
        {
          "name": "SJCBF064_D"
        },
        {
          "name": "SJCBF074_D"
        },
        {
          "name": "SJCBF075_D"
        },
        {
          "name": "SJCBF113_D"
        },
        {
          "name": "SJCBF118_D"
        },
        {
          "name": "SJCBF189_D"
        },
        {
          "name": "SJCBF063_D"
        },
        {
          "name": "SJCBF059_D"
        },
        {
          "name": "SJCBF056_D"
        },
        {
          "name": "SJCBF025_D"
        },
        {
          "name": "SJCBF116_D"
        },
        {
          "name": "SJCBF190_D"
        },
        {
          "name": "SJCBF013_D"
        },
        {
          "name": "SJCBF106_D"
        },
        {
          "name": "SJCBF062_D"
        },
        {
          "name": "SJCBF092_D"
        },
        {
          "name": "SJCBF093_D"
        },
        {
          "name": "SJCBF159_D"
        },
        {
          "name": "SJCBF021_D"
        },
        {
          "name": "SJCBF023_D"
        },
        {
          "name": "SJCBF036_D"
        },
        {
          "name": "SJCBF054_D"
        },
        {
          "name": "SJCBF057_D"
        },
        {
          "name": "SJCBF060_D"
        },
        {
          "name": "SJCBF066_D"
        },
        {
          "name": "SJCBF072_D"
        },
        {
          "name": "SJCBF073_D"
        },
        {
          "name": "SJCBF076_D"
        },
        {
          "name": "SJCBF095_D"
        },
        {
          "name": "SJCBF104_D"
        },
        {
          "name": "SJCBF107_D"
        },
        {
          "name": "SJCBF137_D"
        },
        {
          "name": "SJCBF144_D"
        },
        {
          "name": "SJCBF155_D"
        },
        {
          "name": "SJCBF188_D"
        }
      ]
    }
  ],
  "genegroup": [
    {
      "name": " ",
      "lst": [
        {
          "name": "WT1",
          "sortorder": 0
        },
        {
          "name": "MGA",
          "sortorder": 1
        },
        {
          "name": "ZBTB7A",
          "sortorder": 2
        },
        {
          "name": "CCND2",
          "sortorder": 3
        },
        {
          "name": "DHX15",
          "sortorder": 4
        },
        {
          "name": "TET2",
          "sortorder": 5
        },
        {
          "name": "MYC",
          "sortorder": 6
        }
      ]
    },
    {
      "name": "Epigenetics",
      "lst": [
        {
          "name": "ASXL2",
          "sortorder": 7
        },
        {
          "name": "EZH2",
          "sortorder": 8
        },
        {
          "name": "KDM6A",
          "sortorder": 9
        },
        {
          "name": "KMT2C",
          "sortorder": 10
        },
        {
          "name": "KMT2D",
          "sortorder": 11
        },
        {
          "name": "SETD2",
          "sortorder": 12
        },
        {
          "name": "CREBBP",
          "sortorder": 13
        },
        {
          "name": "EED",
          "sortorder": 14
        }
      ]
    },
    {
      "name": "Cohesin",
      "lst": [
        {
          "name": "SMC1A",
          "sortorder": 15
        },
        {
          "name": "RAD21",
          "sortorder": 16
        },
        {
          "name": "SMC3",
          "sortorder": 17
        },
        {
          "name": "ESCO2",
          "sortorder": 18
        }
      ]
    },
    {
      "name": "Signaling",
      "lst": [
        {
          "name": "NRAS",
          "sortorder": 19
        },
        {
          "name": "KIT",
          "sortorder": 20
        },
        {
          "name": "NF1",
          "sortorder": 21
        },
        {
          "name": "FLT3",
          "sortorder": 22
        },
        {
          "name": "KRAS",
          "sortorder": 23
        },
        {
          "name": "CBL",
          "sortorder": 24
        },
        {
          "name": "PHIP",
          "sortorder": 25
        },
        {
          "name": "CSF3R",
          "sortorder": 26
        },
        {
          "name": "GIGYF2",
          "sortorder": 27
        },
        {
          "name": "PTPN11",
          "sortorder": 28
        },
        {
          "name": "ARHGEF10",
          "sortorder": 29
        },
        {
          "name": "DCC",
          "sortorder": 30
        }
      ]
    }
  ],
  "hiddenControls": [],
  "sortGenesBy": "sampleCount",
  "sortGeneGrpsBy": "as listed",
  "sortSamplesBy": "geneRowOrder",
  "sortSampleGrpsBy": "as listed",
  "resortSamples": false,
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF061_D": {
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "yes",
      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "yes",
      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "yes",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
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      "-X/-Y": "no",
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      "-5/-7": "no",
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      "Fusion only": "yes",
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      "Age": "no",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
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      "Del(9q)": "no",
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      "-5/-7": "no",
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      "Fusion only": "yes",
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "yes",
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      "-X/-Y": "no",
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      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "Del(9q)": "no",
      "-X/-Y": "yes",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "-X/-Y": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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      "-X/-Y": "yes",
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      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
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      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "-X/-Y": "yes",
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      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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    },
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      "+8": "no",
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      "Complex": "no",
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    },
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Data unavailable": "no"
    },
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
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      "-X/-Y": "yes",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
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      "-5/-7": "no",
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      "Fusion only": "no",
      "Data unavailable": "no"
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "yes",
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
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      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
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    },
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      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
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    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
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    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
      "Data unavailable": "yes"
    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
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    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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    },
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      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
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    },
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      "+8": "no",
      "-5/-7": "no",
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      "Fusion only": "no",
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    },
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      "-X/-Y": "yes",
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      "-5/-7": "no",
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    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
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    },
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      "-X/-Y": "yes",
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      "-5/-7": "yes",
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      "Data unavailable": "no"
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
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    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
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    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "yes",
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      "Fusion only": "no",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "yes",
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    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
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    },
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      "Age": "yes",
      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "no",
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    },
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      "Del(9q)": "no",
      "-X/-Y": "no",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "no",
      "Fusion only": "yes",
      "Data unavailable": "no"
    },
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      "Del(9q)": "no",
      "-X/-Y": "yes",
      "+8": "no",
      "-5/-7": "no",
      "Complex": "yes",
      "Fusion only": "no",
      "Data unavailable": "no"
    },
    "SJCBF147_D": {
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The mutational landscape of core-binding factor acute myeloid leukemias

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