Pan-neuroblastoma analysis reveals age- and signature 18 associated drivers and recurrent FGFR1 mutations

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

Oct 13, 2020

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A collection of modularized chart renderers, typically called from ProteinPaint.

Heatmap of mutated genes across neuroblastoma cohort analyzed in Brady et al. 2020 (heatmap representative of Fig. 1) identifying of age- and signature 18 associated drivers and recurrent FGFR1 mutations. For each sample age, coding mutations, stage, WGS availability, and various chromosomal abnormalities are indicated. Mutations in genes (rows) are defined as per legend, as are altered copy number states. Mousing over each instance of a mutation provides further information (sample, mutation type, amino acid change, and gene name). Clicking on each gene symbol opens a ProteinPaint view of mutations found within the gene within samples in this cohort. Numbers in parentheses next to each gene symbol indicate the number of samples altered.

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