Sickle Cell Disease Pain Study

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital

Feb 1, 2020

1.5K

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Visualization of somatic coding and noncoding alterations from ~3,800 pediatric tumors, along with multi-omics information to reveal oncogene activation by noncoding alterations, enhancer hijacking, aberrant splicing, mutual-exclusivity, mutation signature, and more.

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Build of the reference genome used for this visualization.
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View single nucleotide variants and small indels that have been annotated with pain data. Variants within the KIAA1109-TENR-IL2-IL21 locus have been analyzed for genetic association with pain rate and time to first pain event within our sickle cell disease cohort. Tracks within the browser, which can be selected from the "Tracks" menu, include the pain rate and time to first VOC event p-values, average pain rate by genotype, and average fetal hemoglobin by genotype.

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