The genomic landscape of mixed phenotype acute leukemia.
Heatmap summarizing recurrently altered genes within mixed phenotype acute leukemia (MPAL) subtypes (T-cell and myeloid lineage (T/M), B-cell and myeloid lineage (B/M), KMT2A-rearranged (KMT2Ar), acute undifferentiated leukemia (AUL), not otherwise specified (NOS), Philadelphia chromosome (Ph+)). Data sources (WGS, WES, RNA-Seq, SNP array) along with germline status, MPAL presentation, age, initial therapy, outcome, and prediction analysis of microarrays (PAM) subtype are also indicated. Heatmap representative of Fig. 1b,c of Alexander et al. 2018. Mutations in genes (rows) are defined as per legend. Mousing over each instance of a mutation provides further information (sample, mutation type, amino acid change, and gene name). Numbers in parentheses next to each gene symbol indicate the number of samples altered.