Audacious Goals Initiative (AGI) - Retina

nei.nih.gov
17
62.6K
Sep 23, 2021

The Audacious Goals Initiative (AGI) for Regenerative Medicine is an effort by the National Eye Institute (NEI) to push the boundaries of vision science and restore vision through regeneration of the retina. By facilitating cross-disciplinary research, we are tackling the most devastating and difficult-to-treat eye diseases.

Molecular Discovery for Optic Nerve Regeneration (Goldberg Lab)

The aim of this project is to identify genes and proteins that promote or inhibit the ability of retinal ganalion cells to regenerate axons and form functional synaptic connections. This work has been published in the following manuscripts:

See the following visualizations to explore the findings:

See the summary and/or data for this project on the Data tab above.

Another project, with collaboration from the lab of Dan Geschwind (UCLA), was to study transcription factors that drive the program of optic nerve regeneration with extensive bioinformatics work and spinal cord data. This work has been published in the following manuscripts:

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice (2022-08-29)

Novel Targets to Promote RGC Axon Regeneration (Park Lab)

The aim of this project is to idenity genes and lipids that give subtypes of retinal gnaglion cells a greate propensity to regenerate axons and form function synaptic connections. This work has been published in the following manuscripts:

See the following visualizations to explore the findings:

See the summary and/or data for this project on the Data tab above.

Evaluation of Novel Targets for RGC Axon Regeneration (Strittmater Lab)

The aim of this project is to evaluate 450 candidate genes for their ability to regenerate retinal ganglion cell axons. This work has been published in the following manuscripts:

See the summary and/or data for this project on the Data tab above.

Searching for Molecules that Promote Photoreceptor Synaptogenesis (Zack Lab)

The aim of this project is to idenitfy small molecules that influence human photoreceptor neurite outgrpwth and bipolar neuron synaptogenesis. This work has been published in the following manuscripts:

See the following visualizations to explore the findings:

Comparative transcriptomic and Epigenetic Analyses of Müller glia Reprogramming (Hyde Lab)

The aim of this project is to compare the changes in gene expression and chromatin accesssibility in Müller glia from species that can regenerate neurons and those that cannot. This work has been published in the following manuscripts:

See the following visualizations to explore the findings:

See the summary and/or data for this project on the Data tab above.

Novel Activators of Regeneration in Müller glia (Levine Lab)

The aim of this project is to study the regenerative role of extracellular vesicalus in Müller glia in mice and fish. This work has been published in the following manuscripts:

See the following visualizations to explore the findings:

See the summary and/or data for this project on the Data tab above.