Audacious Goals Initiative (AGI) - Retina
The Audacious Goals Initiative (AGI) for Regenerative Medicine is an effort by the National Eye Institute (NEI) to push the boundaries of vision science and restore vision through regeneration of the retina. By facilitating cross-disciplinary research, we are tackling the most devastating and difficult-to-treat eye diseases.
Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice
Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-Ya Gilbert, Yan Ao, Jing Ou, Catherine J Fricano-Kugler, Jeffrey L Goldberg, Zhigang He, Clifford J Woolf, Michael V Sofroniew, Larry I Benowitz, Daniel H Geschwind
Quantitative BONCAT Allows Identification of Newly Synthesized Proteins after Optic Nerve Injury
Sahil H Shah, Lucio M Schiapparelli, Satoshi Yokota, Yuanhui Ma, Xin Xia, Sahana Shankar, Sarah Saturday, Michael Nahmou, Catalina Sun, John Yates 3rd, Hollis T Cline, Jeffrey L Goldberg
Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration
Sahil H Shah, Lucio M Schiapparelli, Yuanhui Ma, Satoshi Yokota, Melissa Atkins, Xin Xia, Evan G Cameron, Thanh Huang, Sarah Saturday, Catalina B Sun, Cara Knasel, Seth Blackshaw, John R Yates, Hollis T Cline, Jeffrey L Goldberg
Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light-damaged zebrafish retina
Leah J Campbell , Joshua S Hobgood , Meng Jia , Patrick Boyd , Rebecca I Hipp , David R Hyde
Gene regulatory networks controlling vertebrate retinal regeneration
Thanh Hoang, Jie Wang, Patrick Boyd, Fang Wang, Clayton Santiago, Lizhi Jiang, Sooyeon Yoo, Manuela Lahne, Levi J Todd, Meng Jia, Cristian Saez, Casey Keuthan, Isabella Palazzo, Natalie Squires, Warren A Campbell, Fatemeh Rajaii, Trisha Parayil, Vickie Trinh, Dong Won Kim, Guohua Wang, Leah J Campbell, John Ash, Andy J Fischer, David R Hyde, Jiang Qian, Seth Blackshaw
Induction of a proliferative response in the zebrafish retina by injection of extracellular vesicles
Dominic Didiano , Jessica J Abner , Scott A Hinger , Zachary Flickinger , Matthew Kent , Margaret A Clement , Sankarathi Balaiya , Qi Liu , Xiaozhuan Dai , Edward M Levine , James G Patton
The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
Dong Won Kim , Parris Whitney Washington, Zoe Qianyi Wang, Sonia Hao Lin, Changyu Sun, Basma Taleb Ismail, Hong Wang , Lizhi Jiang , Seth Blackshaw
Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development.
Yufeng Lu , Fion Shiau , Wenyang Yi , Suying Lu , Qian Wu , Joel D Pearson , Alyssa Kallman , Suijuan Zhong , Thanh Hoang , Zhentao Zuo 8, Fangqi Zhao , Mei Zhang , Nicole Tsai , Yan Zhuo , Sheng He , Jun Zhang , Genevieve L Stein-O'Brien , Thomas D Sherman , Xin Duan , Elana J Fertig , Loyal A Goff , Donald J Zack , James T Handa , Tian Xue , Rod Bremner , Seth Blackshaw , Xiaoqun Wang , Brian S Clark
Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells
Eric R Bray , Benjamin J Yungher , Konstantin Levay , Marcio Ribeiro , Gennady Dvoryanchikov , Ana C Ayupe , Kinjal Thakor , Victoria Marks , Michael Randolph , Matt C Danzi , Tiffany M Schmidt , Nirupa Chaudhari , Vance P Lemmon , Samer Hattar , Kevin K Park
The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo
Lucio M Schiapparelli, Sahil H Shah, Yuanhui Ma, Daniel B McClatchy, Pranav Sharma, Jianli Li, John R Yates 3rd, Jeffrey L Goldberg, Hollis T Cline
Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification
Brian S Clark, Genevieve L Stein-O'Brien , Fion Shiau , Gabrielle H Cannon , Emily Davis-Marcisak , Thomas Sherman , Clayton P Santiago , Thanh V Hoang , Fatemeh Rajaii , Rebecca E James-Esposito , Richard M Gronostajski, Elana J Fertig, Loyal A Goff, Seth Blackshaw
Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration
Anna Trzeciecka, Tal Carmy, Abigail S. Hackam, and Sanjoy K. Bhattacharya
Decomposing Cell Identity for Transfer Learning across Cellular Measurements, Platforms, Tissues, and Species
Genevieve L Stein-O'Brien, Brian S Clark, Thomas Sherman, Cristina Zibetti, Qiwen Hu, Rachel Sealfon, Sheng Liu, Jiang Qian, Carlo Colantuoni, Seth Blackshaw, Loyal A Goff, Elana J Fertig
Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration
Yuichi Sekine, Alexander Lin-Moore, Devon M Chenette, Xingxing Wang, Zhaoxin Jiang, William B Cafferty, Marc Hammarlund, Stephen M Strittmatter
Novel approach to single cell RNA-seq analysis facilitates in silico gene reporting of human pluripotent stem cell-derived retinal cell types
M. Joseph Phillips, Peng Jiang, Sara Howden, Patrick Barney, Jee Min, Nathaniel W. York, Li-Fang Chu, Elizabeth E. Capowski, Abigail Cash, Shivani Jain, Katherine Barlow, Tasnia Tabassum, Ron Stewart, Bikash R. Pattnaik, James A. Thomson, and David M. Gamm