Audacious Goals Initiative (AGI) - Retina

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Sep 22, 2021

The Audacious Goals Initiative (AGI) for Regenerative Medicine is an effort by the National Eye Institute (NEI) to push the boundaries of vision science and restore vision through regeneration of the retina. By facilitating cross-disciplinary research, we are tackling the most devastating and difficult-to-treat eye diseases.

Aug 29, 2022Nature CommunicationsPMID 35906210

Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice

Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-Ya Gilbert, Yan Ao, Jing Ou, Catherine J Fricano-Kugler, Jeffrey L Goldberg, Zhigang He, Clifford J Woolf, Michael V Sofroniew, Larry I Benowitz, Daniel H Geschwind

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May 11, 2022Journal of NeurosciencePMID 35396330

Quantitative BONCAT Allows Identification of Newly Synthesized Proteins after Optic Nerve Injury

Sahil H Shah, Lucio M Schiapparelli, Satoshi Yokota, Yuanhui Ma, Xin Xia, Sahana Shankar, Sarah Saturday, Michael Nahmou, Catalina Sun, John Yates 3rd, Hollis T Cline, Jeffrey L Goldberg

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Mar 08, 2022eLifePMID 35259089

Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration

Sahil H Shah, Lucio M Schiapparelli, Yuanhui Ma, Satoshi Yokota, Melissa Atkins, Xin Xia, Evan G Cameron, Thanh Huang, Sarah Saturday, Catalina B Sun, Cara Knasel, Seth Blackshaw, John R Yates, Hollis T Cline, Jeffrey L Goldberg

Mar 01, 2021 PMID 32965734

Notch3 and DeltaB maintain Müller glia quiescence and act as negative regulators of regeneration in the light-damaged zebrafish retina

Leah J Campbell , Joshua S Hobgood , Meng Jia , Patrick Boyd , Rebecca I Hipp , David R Hyde

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Nov 19, 2020SciencePMID 33004674

Gene regulatory networks controlling vertebrate retinal regeneration

Thanh Hoang, Jie Wang, Patrick Boyd, Fang Wang, Clayton Santiago, Lizhi Jiang, Sooyeon Yoo, Manuela Lahne, Levi J Todd, Meng Jia, Cristian Saez, Casey Keuthan, Isabella Palazzo, Natalie Squires, Warren A Campbell, Fatemeh Rajaii, Trisha Parayil, Vickie Trinh, Dong Won Kim, Guohua Wang, Leah J Campbell, John Ash, Andy J Fischer, David R Hyde, Jiang Qian, Seth Blackshaw

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Nov 01, 2020Exp Eye ResPMID 32961174

Induction of a proliferative response in the zebrafish retina by injection of extracellular vesicles

Dominic Didiano , Jessica J Abner , Scott A Hinger , Zachary Flickinger , Matthew Kent , Margaret A Clement , Sankarathi Balaiya , Qi Liu , Xiaozhuan Dai , Edward M Levine , James G Patton

Aug 31, 2020Nature CommunicationsPMID 32868762

The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development

Dong Won Kim , Parris Whitney Washington, Zoe Qianyi Wang, Sonia Hao Lin, Changyu Sun, Basma Taleb Ismail, Hong Wang , Lizhi Jiang , Seth Blackshaw

May 18, 2020Developmental CellPMID 32386599

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development.

Yufeng Lu , Fion Shiau , Wenyang Yi , Suying Lu , Qian Wu , Joel D Pearson , Alyssa Kallman , Suijuan Zhong , Thanh Hoang , Zhentao Zuo 8, Fangqi Zhao , Mei Zhang , Nicole Tsai , Yan Zhuo , Sheng He , Jun Zhang , Genevieve L Stein-O'Brien , Thomas D Sherman , Xin Duan , Elana J Fertig , Loyal A Goff , Donald J Zack , James T Handa , Tian Xue , Rod Bremner , Seth Blackshaw , Xiaoqun Wang , Brian S Clark

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Aug 21, 2019NeuronPMID 31255486

Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells

Eric R Bray , Benjamin J Yungher , Konstantin Levay , Marcio Ribeiro , Gennady Dvoryanchikov , Ana C Ayupe , Kinjal Thakor , Victoria Marks , Michael Randolph , Matt C Danzi , Tiffany M Schmidt , Nirupa Chaudhari , Vance P Lemmon , Samer Hattar , Kevin K Park

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Aug 13, 2019Cell ReportsPMID 31412257

The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo

Lucio M Schiapparelli, Sahil H Shah, Yuanhui Ma, Daniel B McClatchy, Pranav Sharma, Jianli Li, John R Yates 3rd, Jeffrey L Goldberg, Hollis T Cline

Jun 19, 2019NeuronPMID 31128945

Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification

Brian S Clark, Genevieve L Stein-O'Brien , Fion Shiau , Gabrielle H Cannon , Emily Davis-Marcisak , Thomas Sherman , Clayton P Santiago , Thanh V Hoang , Fatemeh Rajaii , Rebecca E James-Esposito , Richard M Gronostajski, Elana J Fertig, Loyal A Goff, Seth Blackshaw

May 24, 2019Data in BriefPMID 31508459

Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration

Anna Trzeciecka, Tal Carmy, Abigail S. Hackam, and Sanjoy K. Bhattacharya

May 22, 2019Cell SystemsPMID 31121116

Decomposing Cell Identity for Transfer Learning across Cellular Measurements, Platforms, Tissues, and Species

Genevieve L Stein-O'Brien, Brian S Clark, Thomas Sherman, Cristina Zibetti, Qiwen Hu, Rachel Sealfon, Sheng Liu, Jiang Qian, Carlo Colantuoni, Seth Blackshaw, Loyal A Goff, Elana J Fertig

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Apr 10, 2018Cell ReportsPMID 29972787

Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration

Yuichi Sekine, Alexander Lin-Moore, Devon M Chenette, Xingxing Wang, Zhaoxin Jiang, William B Cafferty, Marc Hammarlund, Stephen M Strittmatter

Mar 01, 2018Stem CellsPMID 29230913

Novel approach to single cell RNA-seq analysis facilitates in silico gene reporting of human pluripotent stem cell-derived retinal cell types

M. Joseph Phillips, Peng Jiang, Sara Howden, Patrick Barney, Jee Min, Nathaniel W. York, Li-Fang Chu, Elizabeth E. Capowski, Abigail Cash, Shivani Jain, Katherine Barlow, Tasnia Tabassum, Ron Stewart, Bikash R. Pattnaik, James A. Thomson, and David M. Gamm