Sickle Cell Community
The Sickle Cell Disease Community, an initiative led by St. Jude Children’s Research Hospital, shares whole genome sequencing data and clinical data with research and clinical communities. Our goal is to promote global collaborative efforts to identify genetic modifiers of sickle cell disease complications, improve clinical management for patients, and develop more effective treatments.
A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease
Evadnie Rampersaud , Guolian Kang , Lance E Palmer , Sara R Rashkin , Shuoguo Wang , Wenjian Bi , Nicole M Alberts , Doralina Anghelescu , Martha Barton , Kirby Birch , Nidal Boulos , Amanda M Brandow , Russell John Brooke , Ti-Cheng Chang , Wenan Chen , Yong Cheng , Juan Ding , John Easton , Jason R Hodges , Celeste K Kanne , Shawn Levy , Heather Mulder , Ashwin P Patel , Latika Puri , Celeste Rosencrance , Michael Rusch , Yadav Sapkota , Edgar Sioson , Akshay Sharma , Xing Tang , Andrew Thrasher , Winfred Wang , Yu Yao , Yutaka Yasui , Donald Yergeau , Jane S Hankins , Vivien A Sheehan , James R Downing , Jeremie H Estepp , Jinghui Zhang , Michael DeBaun , Gang Wu , Mitchell J Weiss
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
Alexander Teumer, Yong Li , Sahar Ghasemi , Bram P Prins , Matthias Wuttke , Tobias Hermle , Ayush Giri , Karsten B Sieber , Chengxiang Qiu , Holger Kirsten , Adrienne Tin , Audrey Y Chu , Nisha Bansal , Mary F Feitosa , Lihua Wang , Jin-Fang Chai, Massimiliano Cocca , Christian Fuchsberger , Mathias Gorski , Anselm Hoppmann , Katrin Horn , Man Li , Jonathan Marten , Damia Noce , Teresa Nutile , Sanaz Sedaghat , Gardar Sveinbjornsson , Bamidele O Tayo , Peter J van der Most , Yizhe Xu , Zhi Yu , Lea Gerstner , Johan Ãrnlöv , Stephan J L Bakker, Daniela Baptista , Mary L Biggs , Eric Boerwinkle , Hermann Brenner , Ralph Burkhardt , Robert J Carroll , Miao-Li Chee , Miao-Ling Chee , Mengmeng Chen , Ching-Yu Cheng , James P Cook , Josef Coresh , Tanguy Corre , John Danesh , Martin H de Borst , Alessandro De Grandi , Renée de Mutsert , Aiko P J de Vries , Frauke Degenhardt , Katalin Dittrich , Jasmin Divers , Kai-Uwe Eckardt , Georg Ehret , Karlhans Endlich , Janine F Felix , Oscar H Franco , Andre Franke , Barry I Freedman , Sandra Freitag-Wolf , Ron T Gansevoort , Vilmantas Giedraitis , Martin Gögele , Franziska Grundner-Culemann , Daniel F Gudbjartsson , Vilmundur Gudnason , Pavel Hamet , Tamara B Harris , Andrew A Hicks , Hilma Holm , Valencia Hui Xian Foo , Shih-Jen Hwang , M Arfan Ikram , Erik Ingelsson , Vincent W V Jaddoe , Johanna Jakobsdottir , Navya Shilpa Josyula , Bettina Jung , Mika Kähönen , Chiea-Chuen Khor , Wieland Kiess , Wolfgang Koenig , Antje Körner , Peter Kovacs , Holly Kramer , Bernhard K Krämer , Florian Kronenberg , Leslie A Lange , Carl D Langefeld , Jeannette Jen-Mai Lee , Terho Lehtimäki , Wolfgang Lieb , Su-Chi Lim , Lars Lind , Cecilia M Lindgren , Jianjun Liu , Markus Loeffler , Leo-Pekka Lyytikäinen , Anubha Mahajan , Joseph C Maranville , Deborah Mascalzoni , Barbara McMullen , Christa Meisinger , Thomas Meitinger , Kozeta Miliku , Dennis O Mook-Kanamori , Martina Müller-Nurasyid , Josyf C Mychaleckyj , Matthias Nauck , Kjell Nikus , Boting Ning , Raymond Noordam , Jeffrey O' Connell , Isleifur Olafsson , Nicholette D Palmer , Annette Peters , Anna I Podgornaia , Belen Ponte , Tanja Poulain , Peter P Pramstaller , Ton J Rabelink , Laura M Raffield , Dermot F Reilly , Rainer Rettig , Myriam Rheinberger , Kenneth M Rice , Fernando Rivadeneira , Heiko Runz , Kathleen A Ryan , Charumathi Sabanayagam , Kai-Uwe Saum , Ben Schöttker , Christian M Shaffer , Yuan Shi , Albert V Smith , Konstantin Strauch , Michael Stumvoll , Benjamin B Sun , Silke Szymczak , E-Shyong Tai , Nicholas Y Q Tan , Kent D Taylor , Andrej Teren , Yih-Chung Tham , Joachim Thiery , Chris H L Thio , Hauke Thomsen , Unnur Thorsteinsdottir , Anke Tönjes , Johanne Tremblay , André G Uitterlinden , Pim van der Harst , Niek Verweij , Suzanne Vogelezang , Uwe Völker , Melanie Waldenberger , Chaolong Wang , Otis D Wilson , Charlene Wong , Tien-Yin Wong , Qiong Yang , Masayuki Yasuda , Shreeram Akilesh , Murielle Bochud , Carsten A Böger , Olivier Devuyst , Todd L Edwards , Kevin Ho , Andrew P Morris , Afshin Parsa , Sarah A Pendergrass , Bruce M Psaty , Jerome I Rotter , Kari Stefansson , James G Wilson , Katalin Susztak , Harold Snieder , Iris M Heid , Markus Scholz , Adam S Butterworth , Adriana M Hung , Cristian Pattaro , Anna Köttgen
Transient receptor potential polymorphism and haplotype associate with crisis pain in sickle cell disease
Ellie H Jhun , Xiaoyu Hu , Nilanjana Sadhu , Yingwei Yao , Ying He , Diana J Wilkie , Robert E Molokie , Zaijie J Wang
Data Access and Interactive Visualization of Whole Genome Sequence of Sickle Cell Patients within the St. Jude Cloud
Lance E. Palmer, PhD, Xin Zhou, PhD, Clay McLeod, Evadnie Rampersaud, PhD, Jeremie H. Estepp, MD, Xing Tang, PhD, Jian Wang, Edgar Siosan, J. Robert Michael, Kirby Birch, Jason R Hodges, PhD MA, Martha Villavicencio, PhD, Michael Rusch, BS, Scott Newman, PhD, Heather Mulder, BS, John Easton, PhD, Keith Perry, James R. Downing, MD, Jane S. Hankins, MD MS, Gang Wu, PhD, Jinghui Zhang, Mitchell J. Weiss, MD PhD
Genetic variants of GCH1 associate with chronic and acute crisis pain in African Americans with sickle cell disease
Nilanjana Sadhu , Ellie H Jhun , Yingwei Yao , Ying He , Robert E Molokie , Diana J Wilkie , Zaijie Jim Wang
Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell disease
Ellie H Jhun , Nilanjana Sadhu , Yingwei Yao , Ying He , Robert E Molokie , Diana J Wilkie , Zaijie Jim Wang
Sickle Cell Clinical Research and Intervention Program (SCCRIP): A lifespan cohort study for sickle cell disease progression from the pediatric stage into adulthood.
Jane S. Hankins, Jeremie H. Estepp, Jason R. Hodges, Martha A. Villavicencio, Leslie L. Robison, Mitchell J. Weiss, Guolian Kang, Jane E. Schreiber, Jerlym S. Porter, Sue C. Kaste, Kay L. Saving, Paulette C. Bryant, Jeffrey E. Deyo, Kerri A. Nottage, Allison A. King, Amanda M. Brandow, Jeffrey D. Lebensburger, Oyebimpe Adesina, Stella T. Chou, Babette S. Zemel, Matthew P. Smeltzer, Winfred C. Wang, James G. Gurney
Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study
Yingze Zhang , Inna Belfer , Mehdi Nouraie , Qilu Zeng , Ruchika Goel , Yanxia Chu , Inna Krasiy , Lakshmanan Krishnamurti
Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia
Isabela Cristina Cordeiro Farias , Taciana Furtado Mendonça-Belmont , Andreia Soares da Silva , Kleyton Palmeira do à , Felipe Ferreira , Fernanda Silva Medeiros , Luydson Richardson da Silva Vasconcelos , Marcos André Cavalcanti Bezerra , Aderson da Silva Araújo , Patricia Muniz Mendes Freire de Moura, Betânia Lucena Domingues Hatzlhofer , Ana Claudia Mendonça Dos Anjos , Maria do Socorro de Mendonça Cavalcanti
IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease
Xiaoyu Hu, Ellie H Jhun, Yingwei Yao, Ying He, Robert E Molokie, Diana J Wilkie, and Zaijie J Wang
Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia
Taciana Furtado de Mendonça Belmont , Kleyton Palmeira do à , Andreia Soares da Silva , Kamila de Melo Vilar , Fernanda Silva Medeiros , Luydson Richardson Silva Vasconcelos 4, Ana Claudia Mendonça Dos Anjos , Betânia Lucena Domingues Hatzlhofer , MaÃra Galdino da Rocha Pitta , Marcos André Cavalcanti Bezerra , Aderson da Silva Araújo , Moacyr Jesus Barreto de Melo Rego , PatrÃcia Moura , Maria do Socorro Mendonça Cavalcanti
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease
Ellie Jhun , Ying He, Yingwei Yao, Robert E Molokie, Diana J Wilkie, Zaijie Jim Wang
A GCH1 haplotype confers sex-specific susceptibility to pain crises and altered endothelial function in adults with sickle cell anemia
Inna Belfer , Victoria Youngblood, Deepika S Darbari, Zhengyuan Wang, Lena Diaw, Lita Freeman, Krupa Desai, Michael Dizon, Darlene Allen, Colin Cunnington, Keith M Channon, Jacqueline Milton, Stephen W Hartley, Vikki Nolan, Gregory J Kato, Martin H Steinberg, David Goldman, James G Taylor 6th
APOL1 risk variants, race, and progression of chronic kidney disease
Afshin Parsa , W H Linda Kao, Dawei Xie, Brad C Astor, Man Li, Chi-yuan Hsu, Harold I Feldman, Rulan S Parekh, John W Kusek, Tom H Greene, Jeffrey C Fink, Amanda H Anderson, Michael J Choi, Jackson T Wright Jr, James P Lash, Barry I Freedman, Akinlolu Ojo, Cheryl A Winkler, Dominic S Raj, Jeffrey B Kopp, Jiang He, Nancy G Jensvold, Kaixiang Tao, Michael S Lipkowitz, Lawrence J Appel; AASK Study Investigators; CRIC Study Investigators
The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease
Hebah H Al-Habboubi , Najat Mahdi, Tala M Abu-Hijleh, Farah M Abu-Hijleh, Mai S Sater, Wassim Y Almawi
Protein Z polymorphisms associated with vaso-occlusive crisis in young sickle cell disease patients
Najat Mahdi , Tala M Abu-Hijleh, Farah M Abu-Hijleh, Mai S Sater, Khadija Al-Ola, Wassim Y Almawi
MYH9 and APOL1 are both associated with sickle cell disease nephropathy
Allison E Ashley-Koch , Emmanuel C Okocha, Melanie E Garrett, Karen Soldano, Laura M De Castro, Jude C Jonassaint, Eugene P Orringer, James R Eckman, Marilyn J Telen
Association of variant alleles of MBL2 gene with vasoocclusive crisis in children with sickle cell anemia
T F Mendonça , M C V C Oliveira, L R S Vasconcelos, L M M B Pereira, P Moura, M A C Bezerra, M N N Santos, A S Araújo, M S M Cavalcanti
Association of the MBL2 Gene EXON1 Polymorphism and Vasoocclusive Crisis in Patients with Sickle Cell Anemia
M.C.V.C. Oliveira; T.F. Mendonça; L.R.S. Vasconcelos; P. Moura; M.A.C. Bezerra; M.N.N. Santos; A.S. Araújo; M.S.M. Cavalcanti
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko , Gary D Slade, Andrea G Nackley, Konakporn Bhalang, Asgeir Sigurdsson, Inna Belfer, David Goldman, Ke Xu, Svetlana A Shabalina, Dmitry Shagin, Mitchell B Max, Sergei S Makarov, William Maixner
Pain in sickle cell disease. Rates and risk factors
O S Platt , B D Thorington, D J Brambilla, P F Milner, W F Rosse, E Vichinsky, T R Kinney