Cancer Survivorship Community
The Cancer Survivorship Community shares high quality genomic, clinical, and patient-reported data from survivors of pediatric cancer. To accelerate the rate of discovery in survivorship research we have developed this SJLIFE Survivorship Portal, a data-sharing platform for genomic and clinical data from the St. Jude Lifetime Cohort hosted on the St. Jude Cloud. The Portal features the Clinical Data Browser, GenomePaint, a genetic variant browser, for browsing, visualizing and analyzing clinical and genetic data integratively. Additionally, the Survivorship Portal will serve as a site for an expanding portfolio of risk-prediction tools developed using the SJLIFE cohort, including the recently developed Cumulative Burden Risk-Prediction Tool.
Reference: Epigenetic Age Acceleration and Chronic Health Conditions among Adult Survivors of Childhood Cancer. JNCI 2021
Risk factors for neurocognitive impairment, emotional distress and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.
van der Plas E, Darji H, Srivastava K, Schapiro M, Jeffe D, Perkins S, Howell R, Leisenring W, Armstrong GT, Oeffinger K, Krull K, Edelstein K, Hayashi RJ.
Movement efficiency in survivors of childhood Acute Lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study.
Onerup A, Mirzaei S, Wogksch MD, Goodenough CG, Lambert G, Sapkota Y, Mulrooney DA, Hudson MM, Jacola LM, Ness KK.
Dietary patterns and their associations with sociodemographic and lifestyle factors in adult survivors of childhood cancer: A cross-sectional study.
Park Y, Lan T, Wang M, Ehrhardt MJ, Lanctot JQ, Jiang S, Armstrong GT, Ness KK, Hudson MM, Colditz GA, Robison LL.
Improved cardiomyopathy risk prediction using global longitudinal strain and N-Terminal-Pro-B-type natriuretic peptide in survivors of childhood cancer exposed to cardiotoxic therapy.
Ehrhardt MJ, Liu Q, Mulrooney DA, Rhea IB, Dixon SB, Lucas JT Jr, Sapkota Y, Shelton K, Ness KK, Srivastava DK, McDonald A, Robison LL, Hudson MM, Yasui Y, Armstrong GT.
Quantitative computed tomography analysis of body composition changes in pediatric patients with Acute Lymphoblastic leukemia
Suwannaying K, Ong AA, Dhaduk R, Pei D, Iijima M, Merkle E, Zhuang TZ, Goodenough CG, Brown J, Browne EK, Wolcott B, Cheng C, Wilson CL, Pui CH, Ness KK, Kaste SC, Inaba H.
The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study.
Murphy AJ, Cheng C, Williams J, Shaw TI, Pinto EM, Dieseldorff-Jones K, Brzezinski J, Renfro LA, Tornwall B, Huff V, Hong AL, Mullen EA, Crompton B, Dome JS, Fernandez CV, Geller JI, Ehrlich PF, Mulder H, Oak N, Maciezsek J, Jablonowski C, Fleming AM, Pichavaram P, Morton CL, Easton J, Nichols KE, Clay MR, Santiago T, Zhang J, Yang J, Zambetti GP, Wang Z, Davidoff AM, Chen X.
Association analysis of self-reported outcomes with a validated subset
Mirzaei S, MartÃnez JM, Chow EJ, Ness KK, Hudson MM, Armstrong GT, Yasui Y.
Financial hardship among siblings of long-term survivors of childhood cancer: A Childhood Cancer Survivor Study report.
Ohlsen TJD, Wang H, Buchbinder D, Huang IC, Desai AD, Zheng Z, Kirchhoff AC, Park ER, Krull K, Conti RM, Yasui Y, Leisenring W, Armstrong GT, Yabroff KR, Nathan PC, Chow EJ.
Genetic factors and long-term treatment-related neurocognitive deficits, anxiety, and depression in childhood leukemia survivors: An exome-wide association study.
Petrykey K, Lippé S, Sultan S, Robaey P, Drouin S, Affret-Bertout L, Beaulieu P, St-Onge P, Baedke JL, Yasui Y, Hudson MM, Laverdière C, Sinnett D, Krajinovic M.
Job lock among survivors of childhood cancer and their spouses post Affordable Care Act implementation: A Childhood Cancer Survivor Study brief report
Waters, Austin R.; Liu, Qi, Ji Xu;Yasui, Yutaka; Yabroff, K. Robin; Conti, Rena M.; Henderson, Tara; Huang, I-Chan; Leisenring, Wendy; Armstrong, Gregory T. A; Nathan, Paul C.; Park, Elyse; Kirchhoff, Anne C.
Association of hearing loss with patient-reported functional outcomes in adult survivors of childhood cancer.
Bass JK, Wang F, Thaxton ME, Warren SE, Srivastava DK, Hudson MM, Ness KK, Brinkman TM. [IN PRESS]
Neurologic morbidity and functional independence in adult survivors of childhood cancer.
Vuotto SC, Wang M, Okcu MF, Bowers DC, Ullrich NJ, Ness KK, Li C, Srivastava DK, Howell RM, Gibson TM, Leisenring WM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR, Brinkman TM.
Trends in physical functioning in Acute Lymphoblastic leukemia and non-Hodgkin lymphoma survivors across three decades.
Wilson CL, Bjornard KL, Partin RE, Kadan-Lottick NS, Nathan PC, Oeffinger K, Hayashi RJ, Hyun G, Armstrong G, Leisenring WM, Howell RM, Yasui Y, Dixon SB, Ehrhardt MJ, Robison LL, Ness KK
Deficit accumulation index and biological markers of aging in survivors of childhood cancer
Williams ALM, Mandelblatt J, Wang M, Dong Q, Armstrong GT, Bhakta N, Brinkman TM, Ehrhardt MJ, Mulrooney DA, Gilmore N, Robison LL, Yasui Y, Small BJ, Srivastava DK, Hudson MM, Ness KK, Krull KR, Wang Z
Dyslipidemia and Cardiovascular Disease Among Childhood Cancer Survivors: A St. Jude Lifetime Cohort Report.
Goldberg JF, Hyun G, Ness KK, Dixon SB, Towbin JA, Rhea IB, Ehrhardt MJ, Srivastava DK, Mulrooney DA, Hudson MM, Robison LL, Jefferies JL, Rohatgi A, Armstrong GT.
Diagnostic Utility of Genome-wide DNA Methylation Analysis in Genetically Unsolved Developmental and Epileptic Encephalopathies and Refinement of a CHD2 Episignature
LaFlamme CW, Rastin C, Sengupta S, Pennington HE, Russ-Hall SJ, Schneider AL, Bonkowski ES, Almanza Fuerte EP, Galey M, Goffena J, Gibson SB, Allan TJ, Nyaga DM, Lieffering N, Hebbar M, Walker EV, Darnell D, Olsen SR, Kolekar P, Djekidel N, Rosikiewicz W, McConkey H, Kerkhof J, Levy MA, Relator R, Lev D, Lerman-Sagie T, Park KL, Alders M, Cappuccio G, Chatron N, Demain L, Genevieve D, Lesca G, Roscioli T, Sanlaville D, Tedder ML, Hubshman MW, Ketkar S, Dai H, Worley KC, Rosenfeld JA, Chao HT; Undiagnosed Diseases Network; Neale G, Carvill GL; University of Washington Center for Rare Disease Research; Wang Z, Berkovic SF, Sadleir LG, Miller DE, Scheffer IE, Sadikovic B, Mefford HC.
Prediabetes and associated risk of cardiovascular events and chronic kidney disease among adult survivors of childhood cancer in the St. Jude Lifetime Cohort
Dixon SB, Wang F, Lu L, Wilson CL, Jefferies JL, Green DM, Merchant TE, Howell RM, Srivastava DK, Delaney A, Robison LL, Ness KK, Hudson MM, Chemaitilly W, Armstrong GT
Evolving therapies, neurocognitive outcomes and functional independence in adult survivors of childhood glioma
Chiara Papini, PhD, MPH, Sedigheh Mirzaei S., PhD, Mengqi Xing, MR, Ingrid Tonning Olsson, PhD, Peter M K de Blank, MD, MSCE, Katharine R Lange, MD, Ralph Salloum, MD, Deokumar Srivastava, PhD, Wendy M Leisenring, ScD, Rebecca M Howell, PhD, Kevin C Oeffinger, MD, Leslie L Robison, PhD, Gregory T Armstrong, MD, MSCE, Kevin R Krull, PhD, Tara M Brinkman, PhD
Refining the genetic risk of breast cancer with rare haplotypes and pattern mining.
William Letsou, Fan Wang, Wonjong Moon, Cindy Im, Yadav Sapkota, Leslie L Robison, Yutaka Yasui
Cardiac substructure radiation dose and risk of late cardiac disease: A report from the Childhood Cancer Survivor Study.
Bates JE, Shrestha S, Liu Q, Smith SA, Mulrooney DA, Leisenring W, Gibson T, Robison LL, Chow EJ, Oeffinger KC, Armstrong GT, Constine LS, Hoppe BS, Lee C, Yasui Y, Howell RM.
Social cognition and adjustment in adult survivors of pediatric central nervous system tumors
Papini C, Willard VW, Gajjar A, Merchant TE, Srivastava DK, Armstrong GT, Hudson MM, Krull KR, Brinkman TM.
Response-shift effects in childhood cancer survivors: A prospective study
I-Chan Huang, Jin-Ah Sim, DeoKumar Srivastava, Kevin R Krull, Kirsten K Ness, Leslie L Robison, Justin N Baker, Melissa M Hudson, Carolyn E Schwartz
The association of neighborhood characteristics and frailty in childhood cancer survivors: A report from the St. Jude Lifetime Cohort Study
Schwartz LF, Dhaduk R, Howell CR, Brinkman TM, Ehrhardt MJ, Delaney A, Srivastava, Lanctot JQ, Armstrong GT, Robison LL, Hudson MM, Ness KK, Henderson TO.
Cancer-Related Worry as a Predictor of 5-Year Physical Activity Level in Childhood Cancer Survivors
Ware M, Krull KR, Brinkman TM, Armstrong GT, Wilson CL, Mulrooney DA, Wang Z, Lanctot JQ, Partin RE, Shelton K, Hudson MM, Robison LL, Ness KK.
Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer
Hagiwara K, Natarajan S, Wang Z, Zubair H, Mulder HL, Plyler E, Thimmaiah P, Dong L, Ma X, Ness KK, Li Z, Mulrooney DA, Wilson CL, Yasui Y, Hudson MM, Easton J, Robison LL, Zhang J.