Cancer Survivorship Community

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Apr 15, 2022

The Cancer Survivorship Community shares high quality genomic, clinical, and patient-reported data from survivors of pediatric cancer. To accelerate the rate of discovery in survivorship research we have developed this SJLIFE Survivorship Portal, a data-sharing platform for genomic and clinical data from the St. Jude Lifetime Cohort hosted on the St. Jude Cloud. The Portal features the Clinical Data Browser, GenomePaint, a genetic variant browser, for browsing, visualizing and analyzing clinical and genetic data integratively. Additionally, the Survivorship Portal will serve as a site for an expanding portfolio of risk-prediction tools developed using the SJLIFE cohort, including the recently developed Cumulative Burden Risk-Prediction Tool.

Reference: Epigenetic Age Acceleration and Chronic Health Conditions among Adult Survivors of Childhood Cancer. JNCI 2021

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Cancer MedicinePMID 39056576

Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)

Rodwin RL, Wang F, Lu L, Li Z, Srivastava DK, Phillips NS, Khan RB, Brinkman TM, Krull KR, Boop FA, Armstrong GT, Merchant TE, Gajjar A, Robison LL, Hudson MM, Kadan-Lottick NS, Ness KK

PMID 39511924

Sexual dysfunction among long-term survivors of Hodgkin lymphoma.

Hanzlik E, Sabin ND, Yoshida T, Delaney A, Xie L, Darji H, Srivastava D, Mulrooney DA, Hudson MM, Krull KR, Khan RB.

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Nature Medicine

Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors.

Gibson TM, Karyadi DM, Hartley SW, Arnold MA, de Gonzalez AB, Conces MR, Howell RM, Kapoor V, Leisenring WM, Neglia JP, Sampson JN, Turcotte LM, Chanock SJ, Armstrong GT, Morton LM.

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Jan 10, 2025 PMID 39792043

Temporal trends of subsequent CNS malignancies among survivors of childhood cancer.

Galvin RT, Chen Y, Yuan Y, Cooney T, Howell R, Smith S, Arnold MA, Conces M, Leisenring W, Armstrong GT, Neglia JP, Turcotte LM.

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Nov 06, 2024 PMID 39502013

The accuracy of estimating equations for the evaluation of kidney function in adult survivors of unilateral, nonmetastatic, non-syndromic Wilms tumor: A pilot study from the St. Jude Lifetime Cohort Study

Green DM, Wang M, Krasin MJ, Davidoff AM, Srivastava D, Jay DW, Ness KK, Shulkin BL, Lanctot JQ, Shelton KC, Brennan RC, Mulrooney DA, Ehrhardt MJ, Dixon SB, Kurt BA, Robison LL, Hudson MM, Spunt SL

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Sep 21, 2024Cancers (Basel)PMID 39335191

Characterization of Patient Activation Among Childhood Cancer Survivors in the St. Jude Lifetime Cohort (SJLIFE)

Ware ME, de la Cruz A, Dong Q, Shelton K, Brinkman TM, Huang I-C, Webster R, Potter B, Krull K, Mirzaei S, Ehrhardt MJ, Hudson MM, Armstrong GT, Ness K

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Sep 17, 2024JNCI Cancer SpectrumPMID 39288319

Neighborhood Vulnerability and Associations with Poor Health-Related Quality-of-Life Among Adult Survivors of Childhood Cancer

Jaesung Choi, Madeline R. Horan, Tara M. Brinkman, D. Kumar Srivastava, Kirsten K. Ness, Gregory T. Armstrong, Melissa M. Hudson, I-Chan Huang

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Aug 21, 2024 PMID 39182687

Keratinocyte carcinomas in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study

Boull C, Chen Y, Im C, Geller A, Sapkota Y, Bates JE, Howell R, Arnold MA, Conces M, Constine LS, Robison L, Yasui Y, Armstrong GT, Neglia JP, Turcotte LM

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Aug 08, 2024Journal of Cancer SurvivorshipPMID 39196461

Associations between perceived cancer impact and measures of health behavior in survivors of childhood cancer

Ware ME, Goodenough CG, Wogksch MD, Krull KR, Brinkman TM, Hebert JR, Willard V, Webster R, Ehrhardt M, Mirzaei S, Armstrong GT, Hudson MM, Ness KK

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Jul 16, 2024 PMID 39431920

Late subsequent leukemia after childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS).

Ghosh T, Hyun G, Conces M, Arnold MA, Howell RM, Henderson TO, McDonald A, Robison LL, Yasui Y, Ness KK, Armstrong GT, Neglia JP, Turcotte LM.

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Jul 15, 2024 PMID 39010279

Long-term outcomes among survivors of childhood osteosarcoma: A report from the Childhood Cancer Survivor Study (CCSS).

Becktell K, Chen Y, Yasui Y, Phelan R, Armstrong GT, Link M, Oeffinger K, Snyder C, Daw N, Weil B, Weldon C, Chow E, Schwartz CL.

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Jul 04, 2024Neuro-OncologyPMID 38963825

Neurocognitive outcomes and functional independence in adult survivors of childhood medulloblastoma diagnosed over three decades

Papini C, Mirzaei S S, Xing M, Tonning Olsson I, Sollum R, de Blank PMK, Lange KR, King TZ, Srivastava DK, Leisenring WM, Howell RM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR, Brinkman TM

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Jun 28, 2024J Natl Cancer Inst .PMID 38941494

Using neurocognitive phenotypes to inform interventions for adult survivors of childhood cancer

Banerjee P, Phillips NS, Liu W, Ehrhardt MJ, Bhakta N, Brinkman TM, Williams ALM, Yasui Y, Khan RB, Srivastava DK, Ness KK, Robison LL, Hudson MM, Krull KR

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Jun 25, 2024Lancet OncologyPMID 38821086

The burden of cardiovascular disease and risk for subsequent major adverse cardiovascular events in survivors of childhood cancer: a prospective, longitudinal analysis from the St Jude Lifetime Cohort Study

Hammoud RA, Liu Q, Dixon SB, Onerup A, Mulrooney DA, Huang IC, Jefferies JL, Rhea IB, Ness KK, Ehrhardt MJ, Hudson MM, Ky B, Bhakta N, Sapkota Y, Yasui Y, Armstrong GT

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May 01, 2024JAMA Netw OpenPMID 38713463

Multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer.

"Horan MR, Srivastava DK, Choi J, Krull KR, Armstrong GT, Ness KK, Hudson MM, Baker JN, Huang IC "

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Apr 09, 2024Cancer DiscoveryPMID 38593228

St. Jude Survivorship Portal: sharing and analyzing large clinical and genomic datasets from pediatric cancer survivors

Gavriel Y. Matt, Edgar Sioson, Kyla Shelton, Jian Wang, Congyu Lu, Airen Zaldivar Peraza, Karishma Gangwani, Robin Paul, Colleen Reilly, Aleksandar Acić, Qi Liu, Stephanie R. Sandor, Clay McLeod, Jaimin Patel, Fan Wang, Cindy Im, Zhaoming Wang, Yadav Sapkota, Carmen L. Wilson, Nickhill Bhakta, Kirsten K. Ness, Gregory T. Armstrong, Melissa M. Hudson, Leslie L. Robison, Jinghui Zhang, Yutaka Yasui, Xin Zhou

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Mar 27, 2024JACC CardioOncologyPMID 39479326

Autonomic dysfunction among adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study.

Groarke JD, Ness KK, Dhaduk R, Plana JC, Durand JB, Luepker RV, Joshi VM, Ehrhardt M, Mulrooney DA, Dixon SB, Nohria A, Green DM, Howell RM, Srivastava DK, Jefferies JL, Robison LL, Hudson MM, Armstrong GT.

Mar 24, 2024Blood AdvancesPMID 38522094

Machine learning to optimize automated RH genotyping using whole-exome sequencing data

Chang TC, Yu J, Wang Z, Hankins JS, Weiss MJ, Wu G, Westhoff CM, Chou ST, Zheng Y

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Mar 24, 2024Eur J EndocrinolPMID 38468563

Hypogonadism and neurocognitive outcomes among childhood cancer survivors

Yoshida T, Alexander T, Xing M, Williams ALM, Lubas M, Brinkman TM, Chemaitilly W, Robison LL, Hudson MM, Krull KR, Delaney A.

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Mar 05, 2024J Natl Cancer Inst .PMID 38445706

Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer

Plonski NM, Pan Y, Chen C, Dong Q, Zhang X, Song N, Shelton K, Easton J, Mulder H, Zhang J, Neale G, Walker E, Wang H, Webster R, Brinkman T, Krull KR, Armstrong GT, Ness KK, Hudson MM, Li Q, Huang IC, Wang Z.

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Mar 01, 2024Nature CancerPMID 38429413

Temporal changes in treatment and late mortality and morbidity in adult survivors of childhood glioma: A report from the Childhood Cancer Survivor Study

de Blank PMK, Lange KR, Xing M, Mirzaei Salehabadi S, Srivastava D, Brinkman TM, Ness KK, Oeffinger KC, Neglia J, Krull KR, Nathan PC, Howell R, Turcotte LM, Leisenring W, Armstrong GT, Okcu MF, Bowers DC

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Feb 21, 2024Clin Cancer ResPMID 38381440

Systemic biological mechanisms of neurocognitive dysfunction in long-term survivors of childhood Hodgkin lymphoma.

Williams ALM, Liu W, Ehrhardt MJ, Mirzaei Salehabadi S, Panoskaltsis-Mortari A, Phillips NS, Mulrooney DA, Flerlage JE, Yasui Y, Srivastava DK, Robison LL, Hudson MM, Ness KK, Sabin ND, Krull KR.

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Feb 19, 2024CancerPMID 38473225

Lifestyle and subsequent malignant neoplasms in childhood cancer survivors: A report from the St. Jude Lifetime Cohort Study.

Onerup A, Bhatia S, Mirzaei Salehabadi S, Ware M, Yasui Y, Joffe L, Turcotte L, Goodenough C, Sapkota Y, Wogksch M, Ehrhardt M, Armstrong GT, Hudson MM, Ness KK.