Cancer Survivorship Community
The Cancer Survivorship Community shares high quality genomic, clinical, and patient-reported data from survivors of pediatric cancer. To accelerate the rate of discovery in survivorship research we have developed this SJLIFE Survivorship Portal, a data-sharing platform for genomic and clinical data from the St. Jude Lifetime Cohort hosted on the St. Jude Cloud. The Portal features the Clinical Data Browser, GenomePaint, a genetic variant browser, for browsing, visualizing and analyzing clinical and genetic data integratively. Additionally, the Survivorship Portal will serve as a site for an expanding portfolio of risk-prediction tools developed using the SJLIFE cohort, including the recently developed Cumulative Burden Risk-Prediction Tool.
Reference: Epigenetic Age Acceleration and Chronic Health Conditions among Adult Survivors of Childhood Cancer. JNCI 2021
Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)
Rodwin RL, Wang F, Lu L, Li Z, Srivastava DK, Phillips NS, Khan RB, Brinkman TM, Krull KR, Boop FA, Armstrong GT, Merchant TE, Gajjar A, Robison LL, Hudson MM, Kadan-Lottick NS, Ness KK
Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors.
Gibson TM, Karyadi DM, Hartley SW, Arnold MA, de Gonzalez AB, Conces MR, Howell RM, Kapoor V, Leisenring WM, Neglia JP, Sampson JN, Turcotte LM, Chanock SJ, Armstrong GT, Morton LM.
Characterization of Patient Activation Among Childhood Cancer Survivors in the St. Jude Lifetime Cohort (SJLIFE)
Ware ME, de la Cruz A, Dong Q, Shelton K, Brinkman TM, Huang I-C, Webster R, Potter B, Krull K, Mirzaei S, Ehrhardt MJ, Hudson MM, Armstrong GT, Ness K
Neighborhood Vulnerability and Associations with Poor Health-Related Quality-of-Life Among Adult Survivors of Childhood Cancer
Jaesung Choi, Madeline R. Horan, Tara M. Brinkman, D. Kumar Srivastava, Kirsten K. Ness, Gregory T. Armstrong, Melissa M. Hudson, I-Chan Huang
Associations between perceived cancer impact and measures of health behavior in survivors of childhood cancer
Ware ME, Goodenough CG, Wogksch MD, Krull KR, Brinkman TM, Hebert JR, Willard V, Webster R, Ehrhardt M, Mirzaei S, Armstrong GT, Hudson MM, Ness KK
Neurocognitive outcomes and functional independence in adult survivors of childhood medulloblastoma diagnosed over three decades
Papini C, Mirzaei S S, Xing M, Tonning Olsson I, Sollum R, de Blank PMK, Lange KR, King TZ, Srivastava DK, Leisenring WM, Howell RM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR, Brinkman TM
Using neurocognitive phenotypes to inform interventions for adult survivors of childhood cancer
Banerjee P, Phillips NS, Liu W, Ehrhardt MJ, Bhakta N, Brinkman TM, Williams ALM, Yasui Y, Khan RB, Srivastava DK, Ness KK, Robison LL, Hudson MM, Krull KR
The burden of cardiovascular disease and risk for subsequent major adverse cardiovascular events in survivors of childhood cancer: a prospective, longitudinal analysis from the St Jude Lifetime Cohort Study
Hammoud RA, Liu Q, Dixon SB, Onerup A, Mulrooney DA, Huang IC, Jefferies JL, Rhea IB, Ness KK, Ehrhardt MJ, Hudson MM, Ky B, Bhakta N, Sapkota Y, Yasui Y, Armstrong GT
Multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer.
"Horan MR, Srivastava DK, Choi J, Krull KR, Armstrong GT, Ness KK, Hudson MM, Baker JN, Huang IC "
St. Jude Survivorship Portal: sharing and analyzing large clinical and genomic datasets from pediatric cancer survivors
Gavriel Y. Matt, Edgar Sioson, Kyla Shelton, Jian Wang, Congyu Lu, Airen Zaldivar Peraza, Karishma Gangwani, Robin Paul, Colleen Reilly, Aleksandar Acić, Qi Liu, Stephanie R. Sandor, Clay McLeod, Jaimin Patel, Fan Wang, Cindy Im, Zhaoming Wang, Yadav Sapkota, Carmen L. Wilson, Nickhill Bhakta, Kirsten K. Ness, Gregory T. Armstrong, Melissa M. Hudson, Leslie L. Robison, Jinghui Zhang, Yutaka Yasui, Xin Zhou
Autonomic dysfunction among adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study.
Groarke JD, Ness KK, Dhaduk R, Plana JC, Durand JB, Luepker RV, Joshi VM, Ehrhardt M, Mulrooney DA, Dixon SB, Nohria A, Green DM, Howell RM, Srivastava DK, Jefferies JL, Robison LL, Hudson MM, Armstrong GT.
Machine learning to optimize automated RH genotyping using whole-exome sequencing data
Chang TC, Yu J, Wang Z, Hankins JS, Weiss MJ, Wu G, Westhoff CM, Chou ST, Zheng Y
Hypogonadism and neurocognitive outcomes among childhood cancer survivors
Yoshida T, Alexander T, Xing M, Williams ALM, Lubas M, Brinkman TM, Chemaitilly W, Robison LL, Hudson MM, Krull KR, Delaney A.
Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer
Plonski NM, Pan Y, Chen C, Dong Q, Zhang X, Song N, Shelton K, Easton J, Mulder H, Zhang J, Neale G, Walker E, Wang H, Webster R, Brinkman T, Krull KR, Armstrong GT, Ness KK, Hudson MM, Li Q, Huang IC, Wang Z.
Temporal changes in treatment and late mortality and morbidity in adult survivors of childhood glioma: A report from the Childhood Cancer Survivor Study
de Blank PMK, Lange KR, Xing M, Mirzaei Salehabadi S, Srivastava D, Brinkman TM, Ness KK, Oeffinger KC, Neglia J, Krull KR, Nathan PC, Howell R, Turcotte LM, Leisenring W, Armstrong GT, Okcu MF, Bowers DC
Systemic biological mechanisms of neurocognitive dysfunction in long-term survivors of childhood Hodgkin lymphoma.
Williams ALM, Liu W, Ehrhardt MJ, Mirzaei Salehabadi S, Panoskaltsis-Mortari A, Phillips NS, Mulrooney DA, Flerlage JE, Yasui Y, Srivastava DK, Robison LL, Hudson MM, Ness KK, Sabin ND, Krull KR.
Risk factors for neurocognitive impairment, emotional distress and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.
van der Plas E, Darji H, Srivastava K, Schapiro M, Jeffe D, Perkins S, Howell R, Leisenring W, Armstrong GT, Oeffinger K, Krull K, Edelstein K, Hayashi RJ.
Lifestyle and subsequent malignant neoplasms in childhood cancer survivors: A report from the St. Jude Lifetime Cohort Study.
Onerup A, Bhatia S, Mirzaei Salehabadi S, Ware M, Yasui Y, Joffe L, Turcotte L, Goodenough C, Sapkota Y, Wogksch M, Ehrhardt M, Armstrong GT, Hudson MM, Ness KK.
Movement efficiency in survivors of childhood Acute Lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study.
Onerup A, Mirzaei S, Wogksch MD, Goodenough CG, Lambert G, Sapkota Y, Mulrooney DA, Hudson MM, Jacola LM, Ness KK.
Dietary patterns and their associations with sociodemographic and lifestyle factors in adult survivors of childhood cancer: A cross-sectional study.
Park Y, Lan T, Wang M, Ehrhardt MJ, Lanctot JQ, Jiang S, Armstrong GT, Ness KK, Hudson MM, Colditz GA, Robison LL.
Improved cardiomyopathy risk prediction using global longitudinal strain and N-Terminal-Pro-B-type natriuretic peptide in survivors of childhood cancer exposed to cardiotoxic therapy.
Ehrhardt MJ, Liu Q, Mulrooney DA, Rhea IB, Dixon SB, Lucas JT Jr, Sapkota Y, Shelton K, Ness KK, Srivastava DK, McDonald A, Robison LL, Hudson MM, Yasui Y, Armstrong GT.
Quantitative computed tomography analysis of body composition changes in pediatric patients with Acute Lymphoblastic leukemia
Suwannaying K, Ong AA, Dhaduk R, Pei D, Iijima M, Merkle E, Zhuang TZ, Goodenough CG, Brown J, Browne EK, Wolcott B, Cheng C, Wilson CL, Pui CH, Ness KK, Kaste SC, Inaba H.
The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study.
Murphy AJ, Cheng C, Williams J, Shaw TI, Pinto EM, Dieseldorff-Jones K, Brzezinski J, Renfro LA, Tornwall B, Huff V, Hong AL, Mullen EA, Crompton B, Dome JS, Fernandez CV, Geller JI, Ehrlich PF, Mulder H, Oak N, Maciezsek J, Jablonowski C, Fleming AM, Pichavaram P, Morton CL, Easton J, Nichols KE, Clay MR, Santiago T, Zhang J, Yang J, Zambetti GP, Wang Z, Davidoff AM, Chen X.
Association analysis of self-reported outcomes with a validated subset
Mirzaei S, MartÃnez JM, Chow EJ, Ness KK, Hudson MM, Armstrong GT, Yasui Y.
Financial hardship among siblings of long-term survivors of childhood cancer: A Childhood Cancer Survivor Study report.
Ohlsen TJD, Wang H, Buchbinder D, Huang IC, Desai AD, Zheng Z, Kirchhoff AC, Park ER, Krull K, Conti RM, Yasui Y, Leisenring W, Armstrong GT, Yabroff KR, Nathan PC, Chow EJ.