Cancer Survivorship Community

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Apr 15, 2022

The Cancer Survivorship Community shares high quality genomic, clinical, and patient-reported data from survivors of pediatric cancer. To accelerate the rate of discovery in survivorship research we have developed this SJLIFE Survivorship Portal, a data-sharing platform for genomic and clinical data from the St. Jude Lifetime Cohort hosted on the St. Jude Cloud. The Portal features the Clinical Data Browser, GenomePaint, a genetic variant browser, for browsing, visualizing and analyzing clinical and genetic data integratively. Additionally, the Survivorship Portal will serve as a site for an expanding portfolio of risk-prediction tools developed using the SJLIFE cohort, including the recently developed Cumulative Burden Risk-Prediction Tool.

Reference: Epigenetic Age Acceleration and Chronic Health Conditions among Adult Survivors of Childhood Cancer. JNCI 2021

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Cancer MedicinePMID 39056576

Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)

Rodwin RL, Wang F, Lu L, Li Z, Srivastava DK, Phillips NS, Khan RB, Brinkman TM, Krull KR, Boop FA, Armstrong GT, Merchant TE, Gajjar A, Robison LL, Hudson MM, Kadan-Lottick NS, Ness KK

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Nature Medicine

Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors.

Gibson TM, Karyadi DM, Hartley SW, Arnold MA, de Gonzalez AB, Conces MR, Howell RM, Kapoor V, Leisenring WM, Neglia JP, Sampson JN, Turcotte LM, Chanock SJ, Armstrong GT, Morton LM.

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Sep 21, 2024Cancers (Basel)PMID 39335191

Characterization of Patient Activation Among Childhood Cancer Survivors in the St. Jude Lifetime Cohort (SJLIFE)

Ware ME, de la Cruz A, Dong Q, Shelton K, Brinkman TM, Huang I-C, Webster R, Potter B, Krull K, Mirzaei S, Ehrhardt MJ, Hudson MM, Armstrong GT, Ness K

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Sep 17, 2024JNCI Cancer SpectrumPMID 39288319

Neighborhood Vulnerability and Associations with Poor Health-Related Quality-of-Life Among Adult Survivors of Childhood Cancer

Jaesung Choi, Madeline R. Horan, Tara M. Brinkman, D. Kumar Srivastava, Kirsten K. Ness, Gregory T. Armstrong, Melissa M. Hudson, I-Chan Huang

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Aug 08, 2024Journal of Cancer SurvivorshipPMID 39196461

Associations between perceived cancer impact and measures of health behavior in survivors of childhood cancer

Ware ME, Goodenough CG, Wogksch MD, Krull KR, Brinkman TM, Hebert JR, Willard V, Webster R, Ehrhardt M, Mirzaei S, Armstrong GT, Hudson MM, Ness KK

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Jul 04, 2024Neuro-OncologyPMID 38963825

Neurocognitive outcomes and functional independence in adult survivors of childhood medulloblastoma diagnosed over three decades

Papini C, Mirzaei S S, Xing M, Tonning Olsson I, Sollum R, de Blank PMK, Lange KR, King TZ, Srivastava DK, Leisenring WM, Howell RM, Oeffinger KC, Robison LL, Armstrong GT, Krull KR, Brinkman TM

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Jun 28, 2024J Natl Cancer Inst .PMID 38941494

Using neurocognitive phenotypes to inform interventions for adult survivors of childhood cancer

Banerjee P, Phillips NS, Liu W, Ehrhardt MJ, Bhakta N, Brinkman TM, Williams ALM, Yasui Y, Khan RB, Srivastava DK, Ness KK, Robison LL, Hudson MM, Krull KR

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Jun 25, 2024Lancet OncologyPMID 38821086

The burden of cardiovascular disease and risk for subsequent major adverse cardiovascular events in survivors of childhood cancer: a prospective, longitudinal analysis from the St Jude Lifetime Cohort Study

Hammoud RA, Liu Q, Dixon SB, Onerup A, Mulrooney DA, Huang IC, Jefferies JL, Rhea IB, Ness KK, Ehrhardt MJ, Hudson MM, Ky B, Bhakta N, Sapkota Y, Yasui Y, Armstrong GT

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May 01, 2024JAMA Netw OpenPMID 38713463

Multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer.

"Horan MR, Srivastava DK, Choi J, Krull KR, Armstrong GT, Ness KK, Hudson MM, Baker JN, Huang IC "

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Apr 09, 2024Cancer DiscoveryPMID 38593228

St. Jude Survivorship Portal: sharing and analyzing large clinical and genomic datasets from pediatric cancer survivors

Gavriel Y. Matt, Edgar Sioson, Kyla Shelton, Jian Wang, Congyu Lu, Airen Zaldivar Peraza, Karishma Gangwani, Robin Paul, Colleen Reilly, Aleksandar Acić, Qi Liu, Stephanie R. Sandor, Clay McLeod, Jaimin Patel, Fan Wang, Cindy Im, Zhaoming Wang, Yadav Sapkota, Carmen L. Wilson, Nickhill Bhakta, Kirsten K. Ness, Gregory T. Armstrong, Melissa M. Hudson, Leslie L. Robison, Jinghui Zhang, Yutaka Yasui, Xin Zhou

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Mar 27, 2024JACC CardioOncology

Autonomic dysfunction among adult survivors of childhood cancer in the St. Jude Lifetime Cohort Study.

Groarke JD, Ness KK, Dhaduk R, Plana JC, Durand JB, Luepker RV, Joshi VM, Ehrhardt M, Mulrooney DA, Dixon SB, Nohria A, Green DM, Howell RM, Srivastava DK, Jefferies JL, Robison LL, Hudson MM, Armstrong GT.

Mar 24, 2024Blood AdvancesPMID 38522094

Machine learning to optimize automated RH genotyping using whole-exome sequencing data

Chang TC, Yu J, Wang Z, Hankins JS, Weiss MJ, Wu G, Westhoff CM, Chou ST, Zheng Y

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Mar 24, 2024Eur J EndocrinolPMID 38468563

Hypogonadism and neurocognitive outcomes among childhood cancer survivors

Yoshida T, Alexander T, Xing M, Williams ALM, Lubas M, Brinkman TM, Chemaitilly W, Robison LL, Hudson MM, Krull KR, Delaney A.

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Mar 05, 2024J Natl Cancer Inst .PMID 38445706

Health-related quality of life and DNA methylation-based aging biomarkers among survivors of childhood cancer

Plonski NM, Pan Y, Chen C, Dong Q, Zhang X, Song N, Shelton K, Easton J, Mulder H, Zhang J, Neale G, Walker E, Wang H, Webster R, Brinkman T, Krull KR, Armstrong GT, Ness KK, Hudson MM, Li Q, Huang IC, Wang Z.

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Mar 01, 2024Nature CancerPMID 38429413

Temporal changes in treatment and late mortality and morbidity in adult survivors of childhood glioma: A report from the Childhood Cancer Survivor Study

de Blank PMK, Lange KR, Xing M, Mirzaei Salehabadi S, Srivastava D, Brinkman TM, Ness KK, Oeffinger KC, Neglia J, Krull KR, Nathan PC, Howell R, Turcotte LM, Leisenring W, Armstrong GT, Okcu MF, Bowers DC

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Feb 21, 2024Clin Cancer ResPMID 38381440

Systemic biological mechanisms of neurocognitive dysfunction in long-term survivors of childhood Hodgkin lymphoma.

Williams ALM, Liu W, Ehrhardt MJ, Mirzaei Salehabadi S, Panoskaltsis-Mortari A, Phillips NS, Mulrooney DA, Flerlage JE, Yasui Y, Srivastava DK, Robison LL, Hudson MM, Ness KK, Sabin ND, Krull KR.

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Feb 19, 2024CancerPMID 38373075

Risk factors for neurocognitive impairment, emotional distress and poor quality of life in survivors of pediatric rhabdomyosarcoma: A report from the Childhood Cancer Survivor Study.

van der Plas E, Darji H, Srivastava K, Schapiro M, Jeffe D, Perkins S, Howell R, Leisenring W, Armstrong GT, Oeffinger K, Krull K, Edelstein K, Hayashi RJ.

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Feb 19, 2024CancerPMID 38473225

Lifestyle and subsequent malignant neoplasms in childhood cancer survivors: A report from the St. Jude Lifetime Cohort Study.

Onerup A, Bhatia S, Mirzaei Salehabadi S, Ware M, Yasui Y, Joffe L, Turcotte L, Goodenough C, Sapkota Y, Wogksch M, Ehrhardt M, Armstrong GT, Hudson MM, Ness KK.

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Feb 03, 2024Journal of Cancer SurvivorshipPMID 38308806

Movement efficiency in survivors of childhood Acute Lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort Study.

Onerup A, Mirzaei S, Wogksch MD, Goodenough CG, Lambert G, Sapkota Y, Mulrooney DA, Hudson MM, Jacola LM, Ness KK.

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Jan 24, 2024American Journal of NutritionPMID 38278365

Dietary patterns and their associations with sociodemographic and lifestyle factors in adult survivors of childhood cancer: A cross-sectional study.

Park Y, Lan T, Wang M, Ehrhardt MJ, Lanctot JQ, Jiang S, Armstrong GT, Ness KK, Hudson MM, Colditz GA, Robison LL.

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Jan 11, 2024Journal of Clinical OncologyPMID 38207238

Improved cardiomyopathy risk prediction using global longitudinal strain and N-Terminal-Pro-B-type natriuretic peptide in survivors of childhood cancer exposed to cardiotoxic therapy.

Ehrhardt MJ, Liu Q, Mulrooney DA, Rhea IB, Dixon SB, Lucas JT Jr, Sapkota Y, Shelton K, Ness KK, Srivastava DK, McDonald A, Robison LL, Hudson MM, Yasui Y, Armstrong GT.

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Jan 10, 2024Br J Haemaol

Quantitative computed tomography analysis of body composition changes in pediatric patients with Acute Lymphoblastic leukemia

Suwannaying K, Ong AA, Dhaduk R, Pei D, Iijima M, Merkle E, Zhuang TZ, Goodenough CG, Brown J, Browne EK, Wolcott B, Cheng C, Wilson CL, Pui CH, Ness KK, Kaste SC, Inaba H.

Dec 18, 2023Nature CommunicationsPMID 38110397

The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition: A Report from the Children's Oncology Group AREN18B5-Q Study.

Murphy AJ, Cheng C, Williams J, Shaw TI, Pinto EM, Dieseldorff-Jones K, Brzezinski J, Renfro LA, Tornwall B, Huff V, Hong AL, Mullen EA, Crompton B, Dome JS, Fernandez CV, Geller JI, Ehrlich PF, Mulder H, Oak N, Maciezsek J, Jablonowski C, Fleming AM, Pichavaram P, Morton CL, Easton J, Nichols KE, Clay MR, Santiago T, Zhang J, Yang J, Zambetti GP, Wang Z, Davidoff AM, Chen X.

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Dec 13, 2023Stat MedPMID 38088465

Association analysis of self-reported outcomes with a validated subset

Mirzaei S, Martínez JM, Chow EJ, Ness KK, Hudson MM, Armstrong GT, Yasui Y.

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Dec 05, 2023Cancer Epidemiol Biomarkers and PreventionPMID 38051303

Genetic factors and long-term treatment-related neurocognitive deficits, anxiety, and depression in childhood leukemia survivors: An exome-wide association study.

Petrykey K, Lippé S, Sultan S, Robaey P, Drouin S, Affret-Bertout L, Beaulieu P, St-Onge P, Baedke JL, Yasui Y, Hudson MM, Laverdière C, Sinnett D, Krajinovic M.